8BAC
Crystal structure of human heparanase in complex with competitive inhibitor GD05
This is a non-PDB format compatible entry.
Summary for 8BAC
Entry DOI | 10.2210/pdb8bac/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 52672.48 |
Authors | Armstrong, Z.,Davies, G.J. (deposition date: 2022-10-11, release date: 2023-03-01, Last modification date: 2024-02-07) |
Primary citation | Doherty, G.G.,Ler, G.J.M.,Wimmer, N.,Bernhardt, P.V.,Ashmus, R.A.,Vocadlo, D.J.,Armstrong, Z.,Davies, G.J.,Maccarana, M.,Li, J.P.,Kayal, Y.,Ferro, V. Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of alpha-Iduronidase, beta-Glucuronidase and Heparanase. Chembiochem, 24:e202200619-e202200619, 2023 Cited by PubMed: 36453606DOI: 10.1002/cbic.202200619 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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