8B0C
Crystal structure of human heparanase in complex with covalent inhibitor VB158
This is a non-PDB format compatible entry.
Summary for 8B0C
Entry DOI | 10.2210/pdb8b0c/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | heparanase, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 52603.28 |
Authors | Armstrong, Z.,Davies, G. (deposition date: 2022-09-07, release date: 2022-12-28, Last modification date: 2024-02-07) |
Primary citation | Borlandelli, V.,Armstrong, Z.,Nin-Hill, A.,Codee, J.D.C.,Raich, L.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H.S. 4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. Chemmedchem, 18:e202200580-e202200580, 2023 Cited by PubMed: 36533564DOI: 10.1002/cmdc.202200580 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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