7U61

Crystal Structure of Anti-Nicotine Antibody NIC311 Fab Complexed with Nicotine

Summary for 7U61

Entry DOI	10.2210/pdb7u61/pdb
Descriptor	NIC311 Fab Heavy Chain, NIC311 Fab Light Chain, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, ... (5 entities in total)
Functional Keywords	mab, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	47391.01
Authors	Rodarte, J.V.,Pancera, M.P.,Liban, T.L. (deposition date: 2022-03-03, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citation	Rodarte, J.V.,Baehr, C.,Hicks, D.,Liban, T.L.,Weidle, C.,Rupert, P.B.,Jahan, R.,Wall, A.,McGuire, A.T.,Strong, R.K.,Runyon, S.,Pravetoni, M.,Pancera, M. Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding. Structure, 31:20-32.e5, 2023 Cited by PubMed: 36513069 DOI: 10.1016/j.str.2022.11.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation