7R9V
Structure of PIK3CA with covalent inhibitor 19
Summary for 7R9V
Entry DOI | 10.2210/pdb7r9v/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide (2 entities in total) |
Functional Keywords | pi3k, p110, pik3ca, pip3, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 110815.03 |
Authors | Burke, J.E.,McPhail, J.A. (deposition date: 2021-06-29, release date: 2022-04-06, Last modification date: 2023-10-18) |
Primary citation | Borsari, C.,Keles, E.,McPhail, J.A.,Schaefer, A.,Sriramaratnam, R.,Goch, W.,Schaefer, T.,De Pascale, M.,Bal, W.,Gstaiger, M.,Burke, J.E.,Wymann, M.P. Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha. J.Am.Chem.Soc., 144:6326-6342, 2022 Cited by PubMed: 35353516DOI: 10.1021/jacs.1c13568 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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