7KL9

Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 4)

Summary for 7KL9

• Entry DOI: 10.2210/pdb7kl9/pdb
• EMDB information: 22916
• Descriptor: Spike glycoprotein, CTC-445.2 inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2, ace2 decoy, mini-protein, inhibitor, covid-19, antiviral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 476488.16

Authors

Barnes, C.O.,Bjorkman, P.J. (deposition date: 2020-10-29, release date: 2020-11-11, Last modification date: 2020-12-16)

• Primary citation: Linsky, T.W.,Vergara, R.,Codina, N.,Nelson, J.W.,Walker, M.J.,Su, W.,Barnes, C.O.,Hsiang, T.Y.,Esser-Nobis, K.,Yu, K.,Reneer, Z.B.,Hou, Y.J.,Priya, T.,Mitsumoto, M.,Pong, A.,Lau, U.Y.,Mason, M.L.,Chen, J.,Chen, A.,Berrocal, T.,Peng, H.,Clairmont, N.S.,Castellanos, J.,Lin, Y.R.,Josephson-Day, A.,Baric, R.S.,Fuller, D.H.,Walkey, C.D.,Ross, T.M.,Swanson, R.,Bjorkman, P.J.,Gale Jr., M.,Blancas-Mejia, L.M.,Yen, H.L.,Silva, D.A.; De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2.; Science, 370:1208-1214, 2020; PubMed: 33154107; DOI: 10.1126/science.abe0075

Experimental method

ELECTRON MICROSCOPY (4.1 Å)