7JWY

Structure of SARS-CoV-2 spike at pH 4.5

Summary for 7JWY

Entry DOI	10.2210/pdb7jwy/pdb
Related	6XLU 6XM0 6XM3 6XM4 6XM5
EMDB information	22251 22253 22254 22255 22256 22515
Descriptor	Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	sars-cov-2 covid19, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	3
Total formula weight	436708.65
Authors	Zhou, T.,Tsybovsky, Y.,Kwong, P.D. (deposition date: 2020-08-26, release date: 2020-11-25, Last modification date: 2021-12-15)
Primary citation	Zhou, T.,Tsybovsky, Y.,Gorman, J.,Rapp, M.,Cerutti, G.,Chuang, G.Y.,Katsamba, P.S.,Sampson, J.M.,Schon, A.,Bimela, J.,Boyington, J.C.,Nazzari, A.,Olia, A.S.,Shi, W.,Sastry, M.,Stephens, T.,Stuckey, J.,Teng, I.T.,Wang, P.,Wang, S.,Zhang, B.,Friesner, R.A.,Ho, D.D.,Mascola, J.R.,Shapiro, L.,Kwong, P.D. Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28:867-879.e5, 2020 Cited by PubMed: 33271067 DOI: 10.1016/j.chom.2020.11.004 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation