7DQ0
Crystal structure of actinomycin D-echinomycin-d(ACGTGCT/AGCTCGT) complex
Summary for 7DQ0
Entry DOI | 10.2210/pdb7dq0/pdb |
Related PRD ID | PRD_000001 PRD_000491 |
Descriptor | DNA (5'-D(P*AP*GP*CP*TP*CP*GP*T)-3'), Actinomycin D, Echinomycin, ... (8 entities in total) |
Functional Keywords | drug-dna complex, dna mismatch, dna unwinding, dna deformation, dna, antibiotic-dna complex, antibiotic/dna |
Biological source | Streptomyces sp. More |
Total number of polymer chains | 4 |
Total formula weight | 6907.27 |
Authors | Satange, R.B.,Hou, M.H. (deposition date: 2020-12-22, release date: 2021-12-29, Last modification date: 2024-07-10) |
Primary citation | Satange, R.,Chang, C.C.,Li, L.Y.,Lin, S.H.,Neidle, S.,Hou, M.H. Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects. Nucleic Acids Res., 2023 Cited by PubMed: 36919604DOI: 10.1093/nar/gkad156 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report