7CKO
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation
Summary for 7CKO
Entry DOI | 10.2210/pdb7cko/pdb |
Related | 6LZ0 |
EMDB information | 30389 |
Descriptor | Monocarboxylate transporter 1, Basigin, 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid (3 entities in total) |
Functional Keywords | proton-coupled monocarboxylate transporter, mct1, basigin, azd3965, single particle cryo-em, latate transporter, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 83557.11 |
Authors | |
Primary citation | Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184:370-, 2021 Cited by PubMed: 33333023DOI: 10.1016/j.cell.2020.11.043 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.95 Å) |
Structure validation
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