7AUE
Melanocortin receptor 4 (MC4R) Gs protein complex
Summary for 7AUE
Entry DOI | 10.2210/pdb7aue/pdb |
EMDB information | 11927 |
Descriptor | Melanocortin receptor 4, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (8 entities in total) |
Functional Keywords | mc4r, melanocortin, obesity, gpcr, agonist, setmelanotide, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 157802.70 |
Authors | Degtjarik, O.,Israeli, H.,Prabahar, V.,Shalev-Benami, M. (deposition date: 2020-11-02, release date: 2021-04-28, Last modification date: 2023-03-15) |
Primary citation | Israeli, H.,Degtjarik, O.,Fierro, F.,Chunilal, V.,Gill, A.K.,Roth, N.J.,Botta, J.,Prabahar, V.,Peleg, Y.,Chan, L.F.,Ben-Zvi, D.,McCormick, P.J.,Niv, M.Y.,Shalev-Benami, M. Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science, 372:808-814, 2021 Cited by PubMed: 33858992DOI: 10.1126/science.abf7958 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.97 Å) |
Structure validation
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