7AJN

Crystal Structure of the first bromodomain of BRD4 in complex with a BzD ligand

Summary for 7AJN

• Entry DOI: 10.2210/pdb7ajn/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-(1-adamantylmethyl)-2-[(7~{R},9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,10,12-tetraen-9-yl]ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, small molecule, benzo-diazepine, adamantane, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15711.61

Authors

Picaud, S.,Hassel-Hart, S.,Tobias, K.,Spencer, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P. (deposition date: 2020-09-29, release date: 2020-12-02, Last modification date: 2024-01-31)

• Primary citation: Picaud, S.,Hassel-Hart, S.,Tobias, K.,Spencer, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.; Crystal Structure of the first bromodomain of BRD4 in complex with a BzD ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.48 Å)