7ZXW
Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor
Summary for 7ZXW
Entry DOI | 10.2210/pdb7zxw/pdb |
Related | 6FSN 7ZHB 7ZKC 7ZLE 7ZLL 7ZLU |
Descriptor | UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | glycoprotein, misfolding, transferase, endoplasmic reticulum, gt24, 5-[(morpholin-4-yl)methyl]quinolin-8-ol |
Biological source | Thermochaetoides thermophila DSM 1495 |
Total number of polymer chains | 1 |
Total formula weight | 36884.78 |
Authors | Le Cornu, J.D.,Ibba, R.,Roversi, P.,Zitzmann, N. (deposition date: 2022-05-23, release date: 2022-11-30, Last modification date: 2024-01-31) |
Primary citation | Caputo, A.T.,Ibba, R.,Le Cornu, J.D.,Darlot, B.,Hensen, M.,Lipp, C.B.,Marciano, G.,Vasiljevic, S.,Zitzmann, N.,Roversi, P. Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint. Front Mol Biosci, 9:960248-960248, 2022 Cited by PubMed: 36589243DOI: 10.3389/fmolb.2022.960248 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.246 Å) |
Structure validation
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