7ZXK
Human IL-27 in complex with neutralizing SRF388 FAb fragment
Summary for 7ZXK
Entry DOI | 10.2210/pdb7zxk/pdb |
Related | 7zg0 |
Descriptor | Interleukin-27 subunit alpha, Interleukin-27 subunit beta, SRF388 Heavy Chain, ... (6 entities in total) |
Functional Keywords | cytokine, heterodimer, neutralizing, antibody |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 192673.51 |
Authors | Bloch, Y.,Skladanowska, K.,Strand, J.,Welin, M.,Logan, D.,Hill, J.,Savvides, S.N. (deposition date: 2022-05-21, release date: 2022-11-02, Last modification date: 2024-01-31) |
Primary citation | Skladanowska, K.,Bloch, Y.,Strand, J.,White, K.F.,Hua, J.,Aldridge, D.,Welin, M.,Logan, D.T.,Soete, A.,Merceron, R.,Murphy, C.,Provost, M.,Bazan, J.F.,Hunter, C.A.,Hill, J.A.,Savvides, S.N. Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41:111490-111490, 2022 Cited by PubMed: 36261006DOI: 10.1016/j.celrep.2022.111490 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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