7YTX
Crystal structure of TLR8 in complex with its antagonist
Summary for 7YTX
Entry DOI | 10.2210/pdb7ytx/pdb |
Related | 3W3G 5WYX |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | toll-like receptor 8, inhibitor, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 195397.83 |
Authors | |
Primary citation | Ishizaka, S.T.,Hawkins, L.,Chen, Q.,Tago, F.,Yagi, T.,Sakaniwa, K.,Zhang, Z.,Shimizu, T.,Shirato, M. A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus. Eur.J.Pharmacol., 957:175962-175962, 2023 Cited by PubMed: 37544422DOI: 10.1016/j.ejphar.2023.175962 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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