7SU0
Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4
Summary for 7SU0
Entry DOI | 10.2210/pdb7su0/pdb |
Descriptor | Cytotoxic T-lymphocyte protein 4, Fab heavy chain, Fab light chain, ... (7 entities in total) |
Functional Keywords | immunoglobulin, checkpoint, antibody, complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 124623.12 |
Authors | |
Primary citation | Lee, P.S.,MacDonald, K.G.,Massi, E.,Chew, P.V.,Bee, C.,Perkins, P.,Chau, B.,Thudium, K.,Lohre, J.,Nandi, P.,Deyanova, E.G.,Barman, I.,Gudmundsson, O.,Dollinger, G.,Sproul, T.,Engelhardt, J.J.,Strop, P.,Rajpal, A. Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14:2024642-2024642, 2022 Cited by PubMed: 35192429DOI: 10.1080/19420862.2021.2024642 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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