7SQ6
Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Summary for 7SQ6
Entry DOI | 10.2210/pdb7sq6/pdb |
EMDB information | 25377 |
Descriptor | Mucolipin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, ... (5 entities in total) |
Functional Keywords | ion channel, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 265487.74 |
Authors | |
Primary citation | Gan, N.,Han, Y.,Zeng, W.,Wang, Y.,Xue, J.,Jiang, Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35131932DOI: 10.1073/pnas.2120404119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.32 Å) |
Structure validation
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