7SAS
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Summary for 7SAS
Entry DOI | 10.2210/pdb7sas/pdb |
EMDB information | 24955 |
Descriptor | Transmembrane protein 106B, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total) |
Functional Keywords | tmem106b, ftld-tdp, amyloid, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 10 |
Total formula weight | 320411.50 |
Authors | Cao, Q.,Jiang, Y.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2021-09-23, release date: 2022-03-09, Last modification date: 2022-05-25) |
Primary citation | Jiang, Y.X.,Cao, Q.,Sawaya, M.R.,Abskharon, R.,Ge, P.,DeTure, M.,Dickson, D.W.,Fu, J.Y.,Ogorzalek Loo, R.R.,Loo, J.A.,Eisenberg, D.S. Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605:304-309, 2022 Cited by PubMed: 35344984DOI: 10.1038/s41586-022-04670-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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