7QN9
Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state
Summary for 7QN9
Entry DOI | 10.2210/pdb7qn9/pdb |
EMDB information | 14071 |
Descriptor | Gamma-aminobutyric acid receptor subunit alpha-4, HEXADECANE, DECANE, ... (11 entities in total) |
Functional Keywords | pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 309095.29 |
Authors | Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. (deposition date: 2021-12-20, release date: 2022-04-13, Last modification date: 2022-04-20) |
Primary citation | Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604:190-194, 2022 Cited by PubMed: 35355020DOI: 10.1038/s41586-022-04517-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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