7QIV
Structure of human C3b in complex with the EWE nanobody
Summary for 7QIV
Entry DOI | 10.2210/pdb7qiv/pdb |
Related | 6EHG 6RU5 |
Descriptor | Complement C3 beta chain, Complement C3b alpha' chain, Nanobody EWE, ... (4 entities in total) |
Functional Keywords | complement, alternative pathway, antibody, nanobody, protein engineering, immune system |
Biological source | Lama glama More |
Total number of polymer chains | 3 |
Total formula weight | 190700.22 |
Authors | Pedersen, H.,Andersen, G.R. (deposition date: 2021-12-16, release date: 2022-02-16, Last modification date: 2024-01-31) |
Primary citation | Pedersen, H.,Jensen, R.K.,Hansen, A.G.,Petersen, S.V.,Thiel, S.,Laursen, N.S.,Andersen, G.R. Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Front Immunol, 13:872536-872536, 2022 Cited by PubMed: 35935935DOI: 10.3389/fimmu.2022.872536 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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