7PRB
Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor GR109
Summary for 7PRB
Entry DOI | 10.2210/pdb7prb/pdb |
Related | 7PR9 |
Descriptor | Glyco_hydro_44 domain-containing protein, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | glycoside hydrolase, carbohydrate, glucuronidase, gh79, hydrolase |
Biological source | Burkholderia pseudomallei (strain K96243) |
Total number of polymer chains | 2 |
Total formula weight | 90694.49 |
Authors | Wu, L.,Armstrong, Z.,Davies, G.J. (deposition date: 2021-09-21, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | de Boer, C.,Armstrong, Z.,Lit, V.A.J.,Barash, U.,Ruijgrok, G.,Boyango, I.,Weitzenberg, M.M.,Schroder, S.P.,Sarris, A.J.C.,Meeuwenoord, N.J.,Bule, P.,Kayal, Y.,Ilan, N.,Codee, J.D.C.,Vlodavsky, I.,Overkleeft, H.S.,Davies, G.J.,Wu, L. Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119:e2203167119-e2203167119, 2022 Cited by PubMed: 35881786DOI: 10.1073/pnas.2203167119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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