7PGK
HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS
Summary for 7PGK
Entry DOI | 10.2210/pdb7pgk/pdb |
Related PRD ID | PRD_900013 |
Descriptor | Hedgehog-interacting protein, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose (2 entities in total) |
Functional Keywords | hhip, hedgehog, morphogen, signalling, glycosaminoglycan, cholesterol, palmitate, secreted, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 22067.94 |
Authors | Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinuskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. (deposition date: 2021-08-14, release date: 2021-12-15, Last modification date: 2021-12-22) |
Primary citation | Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinauskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12:7171-7171, 2021 Cited by PubMed: 34887403DOI: 10.1038/s41467-021-27475-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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