7OR1
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
Summary for 7OR1
Entry DOI | 10.2210/pdb7or1/pdb |
EMDB information | 13037 |
Descriptor | Transient receptor potential cation channel subfamily A member 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide, ... (8 entities in total) |
Functional Keywords | transient receptor potential cation channel subfamily a member 1, membrane protein, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 527319.24 |
Authors | Grieben, M.,Pike, A.C.W.,Saward, B.G.,Wang, D.,Mukhopadhyay, S.M.M.,Moreira, T.,Chalk, R.,MacLean, E.M.,Marsden, B.D.,Burgess-Brown, N.A.,Bountra, C.,Schofield, C.J.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2021-06-04, release date: 2022-06-22) |
Primary citation | Grieben, M.,Saward, B.G.,Pike, A.C.W.,Schofield, C.J.,Carpenter, E.P. Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60 TO BE PUBLISHED, |
Experimental method | ELECTRON MICROSCOPY (2.64 Å) |
Structure validation
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