7OLY
Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions
Summary for 7OLY
Entry DOI | 10.2210/pdb7oly/pdb |
Descriptor | Inhibin beta A chain, Activin receptor type-2B, Fab heavy chain, ... (8 entities in total) |
Functional Keywords | growth factor, receptor, tgfb, signaling, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 90359.90 |
Authors | Hakansson, M.,Rose, N.C.,Castonguay, R.,Logan, D.T.,Krishnan, L. (deposition date: 2021-05-20, release date: 2022-02-23, Last modification date: 2024-01-31) |
Primary citation | Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Krishnan, L.,Chavez, M.,Czepnik, M.,Maguire, M.C.,Grenha, R.,Hakansson, M.,Logan, D.T.,Grinberg, A.V.,Sako, D.,Castonguay, R.,Kumar, R.,Thompson, T.B. Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25:103590-103590, 2022 Cited by PubMed: 35005539DOI: 10.1016/j.isci.2021.103590 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.265 Å) |
Structure validation
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