7NWY
Crystal structure of alpha carbonic anhydrase from schistosoma mansoni with 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide
This is a non-PDB format compatible entry.
Summary for 7NWY
Entry DOI | 10.2210/pdb7nwy/pdb |
Descriptor | Carbonic anhydrase, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | schistosoma mansoni, carbonic anhydrase, metalloenzyme, inhibitor, neglected diseases, sulfonamide, lyase |
Biological source | Schistosoma mansoni (Blood fluke) |
Total number of polymer chains | 2 |
Total formula weight | 73357.39 |
Authors | Angeli, A.,Ferraroni, M. (deposition date: 2021-03-17, release date: 2022-03-30, Last modification date: 2024-01-31) |
Primary citation | Angeli, A.,Ferraroni, M.,Da'dara, A.A.,Selleri, S.,Pinteala, M.,Carta, F.,Skelly, P.J.,Supuran, C.T. Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. J.Med.Chem., 64:10418-10428, 2021 Cited by PubMed: 34232641DOI: 10.1021/acs.jmedchem.1c00840 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.807 Å) |
Structure validation
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