7N4X

Structure of human NPC1L1 mutant-W347R

Summary for 7N4X

• Entry DOI: 10.2210/pdb7n4x/pdb
• EMDB information: 24180
• Descriptor: Isoform 2 of NPC1-like intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: transporter, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 149193.01

Authors

Li, X.,Long, T. (deposition date: 2021-06-04, release date: 2021-09-01, Last modification date: 2022-03-16)

• Primary citation: Long, T.,Liu, Y.,Qin, Y.,DeBose-Boyd, R.A.,Li, X.; Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.; Sci Adv, 7:-, 2021; PubMed: 34407950; DOI: 10.1126/sciadv.abh3997

Experimental method

ELECTRON MICROSCOPY (3.33 Å)