7CGW
Complex structure of PD-1 and tislelizumab Fab
Summary for 7CGW
Entry DOI | 10.2210/pdb7cgw/pdb |
Descriptor | Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, Programmed cell death protein 1, ... (4 entities in total) |
Functional Keywords | tislelizumab, pd-1, antibody, antitumor protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 131561.07 |
Authors | Hong, Y.,Feng, Y.C.,Liu, Y. (deposition date: 2020-07-02, release date: 2021-04-07, Last modification date: 2024-04-03) |
Primary citation | Hong, Y.,Feng, Y.,Sun, H.,Zhang, B.,Wu, H.,Zhu, Q.,Li, Y.,Zhang, T.,Zhang, Y.,Cui, X.,Li, Z.,Song, X.,Li, K.,Liu, M.,Liu, Y. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Febs Open Bio, 11:782-792, 2021 Cited by PubMed: 33527708DOI: 10.1002/2211-5463.13102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
Download full validation report