6ZU8
Crystal structure of human Brachyury G177D variant in complex with Afatinib
Summary for 6ZU8
Entry DOI | 10.2210/pdb6zu8/pdb |
Descriptor | Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ... (4 entities in total) |
Functional Keywords | brachyury, tbxt, afatinib, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 22633.76 |
Authors | Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-07-21, release date: 2020-08-05, Last modification date: 2024-01-31) |
Primary citation | Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. Crystal structure of human Brachyury G177D variant in complex with Afatinib To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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