6ZU8

Crystal structure of human Brachyury G177D variant in complex with Afatinib

Summary for 6ZU8

• Entry DOI: 10.2210/pdb6zu8/pdb
• Descriptor: Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ... (4 entities in total)
• Functional Keywords: brachyury, tbxt, afatinib, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22633.76

Authors

Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-07-21, release date: 2020-08-05, Last modification date: 2024-01-31)

• Primary citation: Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O.; Crystal structure of human Brachyury G177D variant in complex with Afatinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)