6XZU

Complex of C-terminal domain of murine complement C3b with the hC3Nb3 nanobody

Summary for 6XZU

Entry DOI	10.2210/pdb6xzu/pdb
Descriptor	nanobody hC3Nb1, Complement C3 (3 entities in total)
Functional Keywords	complex, complement, nanobody, innate immune system, immune system
Biological source	Lama glama More
Total number of polymer chains	2
Total formula weight	31136.98
Authors	Andersen, G.R.,Pedersen, H. (deposition date: 2020-02-05, release date: 2020-08-12, Last modification date: 2024-01-24)
Primary citation	Pedersen, H.,Jensen, R.K.,Jensen, J.M.B.,Fox, R.,Pedersen, D.V.,Olesen, H.G.,Hansen, A.G.,Christiansen, D.,Mazarakis, S.M.M.,Lojek, N.,Hansen, P.,Gadeberg, T.A.F.,Zarantonello, A.,Laursen, N.S.,Mollnes, T.E.,Johnson, M.B.,Stevens, B.,Thiel, S.,Andersen, G.R. A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. J Immunol., 205:2287-2300, 2020 Cited by PubMed: 32938727 DOI: 10.4049/jimmunol.2000752 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation