6XDG

Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies

Summary for 6XDG

• Entry DOI: 10.2210/pdb6xdg/pdb
• EMDB information: 22137
• Descriptor: Spike protein S1, REGN10933 antibody Fab fragment light chain, REGN10933 antibody Fab fragment heavy chain, ... (6 entities in total)
• Functional Keywords: sars-cov-2, therapeutic antibody, antiviral, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 5
• Total formula weight: 123517.56

Authors

Franklin, M.C.,Saotome, K.,Romero Hernandez, A.,Zhou, Y. (deposition date: 2020-06-10, release date: 2020-06-24, Last modification date: 2021-01-27)

• Primary citation: Hansen, J.,Baum, A.,Pascal, K.E.,Russo, V.,Giordano, S.,Wloga, E.,Fulton, B.O.,Yan, Y.,Koon, K.,Patel, K.,Chung, K.M.,Hermann, A.,Ullman, E.,Cruz, J.,Rafique, A.,Huang, T.,Fairhurst, J.,Libertiny, C.,Malbec, M.,Lee, W.Y.,Welsh, R.,Farr, G.,Pennington, S.,Deshpande, D.,Cheng, J.,Watty, A.,Bouffard, P.,Babb, R.,Levenkova, N.,Chen, C.,Zhang, B.,Romero Hernandez, A.,Saotome, K.,Zhou, Y.,Franklin, M.,Sivapalasingam, S.,Lye, D.C.,Weston, S.,Logue, J.,Haupt, R.,Frieman, M.,Chen, G.,Olson, W.,Murphy, A.J.,Stahl, N.,Yancopoulos, G.D.,Kyratsous, C.A.; Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.; Science, 369:1010-1014, 2020; PubMed: 32540901; DOI: 10.1126/science.abd0827

Experimental method

ELECTRON MICROSCOPY (3.9 Å)