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6VWU

X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha

Summary for 6VWU
Entry DOI10.2210/pdb6vwu/pdb
DescriptorInterleukin-2,Interleukin-2 receptor subunit alpha (1 entity in total)
Functional Keywordscircular permutation, alks 4230, cytokine
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight34464.32
Authors
Losey, H.C. (deposition date: 2020-02-20, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citationLopes, J.E.,Fisher, J.L.,Flick, H.L.,Wang, C.,Sun, L.,Ernstoff, M.S.,Alvarez, J.C.,Losey, H.C.
ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy.
J Immunother Cancer, 8:-, 2020
Cited by
PubMed: 32317293
DOI: 10.1136/jitc-2020-000673
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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