6VP0

Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA

Summary for 6VP0

• Entry DOI: 10.2210/pdb6vp0/pdb
• EMDB information: 21302
• Descriptor: Diacylglycerol O-acyltransferase 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... (5 entities in total)
• Functional Keywords: diacylglycerol acyltransferase 1, mboat, oleoyl-coa, er, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 120961.21

Authors

Wang, L.,Qian, H.,Han, Y.,Nian, Y.,Ren, Z.,Zhang, H.,Hu, L.,Prasad, B.V.V.,Yan, N.,Zhou, M. (deposition date: 2020-02-01, release date: 2020-05-13, Last modification date: 2023-12-13)

• Primary citation: Wang, L.,Qian, H.,Nian, Y.,Han, Y.,Ren, Z.,Zhang, H.,Hu, L.,Prasad, B.V.V.,Laganowsky, A.,Yan, N.,Zhou, M.; Structure and mechanism of human diacylglycerol O-acyltransferase 1.; Nature, 581:329-332, 2020; PubMed: 32433610; DOI: 10.1038/s41586-020-2280-2

Experimental method

ELECTRON MICROSCOPY (3.1 Å)