6VBM

Crystal structure of a S310A mutant of PBP2 from Neisseria gonorrhoeae

Summary for 6VBM

• Entry DOI: 10.2210/pdb6vbm/pdb
• Descriptor: Probable peptidoglycan D,D-transpeptidase PenA, PHOSPHATE ION (3 entities in total)
• Functional Keywords: penicillin-binding protein, transpeptidase domain, antibiotic resistance, hydrolase
• Biological source: Neisseria gonorrhoeae
• Total number of polymer chains: 2
• Total formula weight: 70810.47

Authors

Singh, A.,Davies, C. (deposition date: 2019-12-19, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C.; Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics; J.Biol.Chem., 2020

Experimental method

X-RAY DIFFRACTION (1.71 Å)