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7M0V

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib

Replaces:  6V2Z
Summary for 7M0V
Entry DOI10.2210/pdb7m0v/pdb
DescriptorSerine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordsbraf, mek1, transferase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total formula weight77480.70
Authors
Li, K.,Gonzalez Del-Pino, G.,Ha, B.H.,Park, E.,Eck, M.J. (deposition date: 2021-03-11, release date: 2021-04-21, Last modification date: 2023-10-18)
Primary citationGonzalez-Del Pino, G.L.,Li, K.,Park, E.,Schmoker, A.M.,Ha, B.H.,Eck, M.J.
Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118:-, 2021
Cited by
PubMed: 34470822
DOI: 10.1073/pnas.2107207118
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.16 Å)
Structure validation

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