6UX8
Structure of monobody 33 MLKL N-terminal domain complex
Summary for 6UX8
Entry DOI | 10.2210/pdb6ux8/pdb |
Descriptor | Mixed lineage kinase domain-like protein, Monobody, ZINC ION, ... (4 entities in total) |
Functional Keywords | protein interactions, cell death, ripk3, programmed necrosis, protein engineering, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28977.14 |
Authors | Birkinshaw, R.W.,Petrie, E.J.,Murphy, J.M. (deposition date: 2019-11-07, release date: 2020-04-01, Last modification date: 2023-10-11) |
Primary citation | Petrie, E.J.,Birkinshaw, R.W.,Koide, A.,Denbaum, E.,Hildebrand, J.M.,Garnish, S.E.,Davies, K.A.,Sandow, J.J.,Samson, A.L.,Gavin, X.,Fitzgibbon, C.,Young, S.N.,Hennessy, P.J.,Smith, P.P.C.,Webb, A.I.,Czabotar, P.E.,Koide, S.,Murphy, J.M. Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies. Proc.Natl.Acad.Sci.USA, 117:8468-8475, 2020 Cited by PubMed: 32234780DOI: 10.1073/pnas.1919960117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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