6U81
Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer
Summary for 6U81
Entry DOI | 10.2210/pdb6u81/pdb |
Descriptor | Double homeobox protein 4, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*CP*CP*CP*AP*TP*TP*AP*CP*GP*C)-3'), ... (5 entities in total) |
Functional Keywords | dux tandem homeodomains, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 27033.31 |
Authors | Shi, K.,Aihara, H. (deposition date: 2019-09-04, release date: 2020-02-19, Last modification date: 2023-10-11) |
Primary citation | Klingler, C.,Ashley, J.,Shi, K.,Stiefvater, A.,Kyba, M.,Sinnreich, M.,Aihara, H.,Kinter, J. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. Faseb J., 34:4573-4590, 2020 Cited by PubMed: 32020675DOI: 10.1096/fj.201902696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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