6TXS

The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide

This is a non-PDB format compatible entry.

Summary for 6TXS

• Entry DOI: 10.2210/pdb6txs/pdb
• Descriptor: Moesin, CD44 antigen (3 entities in total)
• Functional Keywords: pip, ferm domain, alzheimer's disease, cd44, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 42114.62

Authors

Bradshaw, W.J.,Katis, V.L.,Kelly, J.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-01-14, release date: 2020-01-29, Last modification date: 2024-02-14)

• Primary citation: Du, Y.,Bradshaw, W.J.,Leisner, T.M.,Annor-Gyamfi, J.K.,Qian, K.,Bashore, F.M.,Sikdar, A.,Nwogbo, F.O.,Ivanov, A.A.,Frye, S.V.,Gileadi, O.,Brennan, P.E.,Levey, A.I.,Axtman, A.D.,Pearce, K.H.,Fu, H.,Katis, V.L.; Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.; J.Biol.Chem., 299:105382-105382, 2023; PubMed: 37866628; DOI: 10.1016/j.jbc.2023.105382

Experimental method

X-RAY DIFFRACTION (2.2 Å)