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6TXQ

The high resolution structure of the FERM domain and helical linker of human moesin

This is a non-PDB format compatible entry.
Summary for 6TXQ
Entry DOI10.2210/pdb6txq/pdb
DescriptorMoesin, ACETATE ION (3 entities in total)
Functional Keywordspip, ferm domain, alzheimer's disease, cd44, protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight41200.43
Authors
Bradshaw, W.J.,Katis, V.L.,Kelly, J.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-01-14, release date: 2020-01-29, Last modification date: 2024-02-14)
Primary citationDu, Y.,Bradshaw, W.J.,Leisner, T.M.,Annor-Gyamfi, J.K.,Qian, K.,Bashore, F.M.,Sikdar, A.,Nwogbo, F.O.,Ivanov, A.A.,Frye, S.V.,Gileadi, O.,Brennan, P.E.,Levey, A.I.,Axtman, A.D.,Pearce, K.H.,Fu, H.,Katis, V.L.
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299:105382-105382, 2023
Cited by
PubMed: 37866628
DOI: 10.1016/j.jbc.2023.105382
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.73 Å)
Structure validation

217705

數據於2024-03-27公開中

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