6TSG
Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG) in complex with TETRAC
Summary for 6TSG
Entry DOI | 10.2210/pdb6tsg/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 3,3',5,5'-TETRAIODOTHYROACETIC ACID (3 entities in total) |
Functional Keywords | pparg, steroid hormone receptor, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32415.62 |
Authors | Chaikuad, A.,Gellrich, L.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-12-20, release date: 2020-07-22, Last modification date: 2024-01-24) |
Primary citation | Gellrich, L.,Heitel, P.,Heering, J.,Kilu, W.,Pollinger, J.,Goebel, T.,Kahnt, A.,Arifi, S.,Pogoda, W.,Paulke, A.,Steinhilber, D.,Proschak, E.,Wurglics, M.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Bischoff, I.,Furst, R.,Merk, D. l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR gamma. J.Med.Chem., 63:6727-6740, 2020 Cited by PubMed: 32356658DOI: 10.1021/acs.jmedchem.9b02150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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