6T9N

CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2

Summary for 6T9N

Entry DOI	10.2210/pdb6t9n/pdb
EMDB information	10418
Descriptor	Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... (6 entities in total)
Functional Keywords	ion channel, transient receptor potential channel, polycystic kidney disease, structural genomics, structural genomics consortium, sgc, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	276891.48
Authors	Wang, Q.,Pike, A.C.W.,Grieben, M.,Baronina, A.,Nasrallah, C.,Shintre, C.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-28, release date: 2019-11-20, Last modification date: 2020-07-29)
Primary citation	Wang, Q.,Corey, R.A.,Hedger, G.,Aryal, P.,Grieben, M.,Nasrallah, C.,Baronina, A.,Pike, A.C.W.,Shi, J.,Carpenter, E.P.,Sansom, M.S.P. Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Structure, 28:169-184.e5, 2020 Cited by PubMed: 31806353 DOI: 10.1016/j.str.2019.11.005 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.96 Å)

Structure validation