6S6W
Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+
Summary for 6S6W
Entry DOI | 10.2210/pdb6s6w/pdb |
Descriptor | Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | aldh1a3 ga11 glioma 2, 6-diphenylimidazo[1, 2-a]pyridine retinaldehyde dehydrogenase inhinitor aldhs, cytosolic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 109408.77 |
Authors | Gelardi, E.L.M.,Quattrini, L.,LaMotta, C.,Ferraris, D.M.,Garavaglia, S. (deposition date: 2019-07-03, release date: 2020-04-22, Last modification date: 2024-01-24) |
Primary citation | Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C. Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells. J.Med.Chem., 63:4603-4616, 2020 Cited by PubMed: 32223240DOI: 10.1021/acs.jmedchem.9b01910 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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