6S1I

Crystal Structure of DYRK1A with small molecule inhibitor

6S1I の概要

• エントリーDOI: 10.2210/pdb6s1i/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: kinase, catalytic domain, phosphorylated, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171179.04

構造登録者

Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (登録日: 2019-06-18, 公開日: 2019-06-26, 最終更新日: 2024-01-24)

• 主引用文献: Henderson, S.H.,Sorrell, F.,Bennett, J.,Hanley, M.T.,Robinson, S.,Hopkins Navratilova, I.,Elkins, J.M.,Ward, S.E.; Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.; Acs Med.Chem.Lett., 11:1620-1626, 2020; PubMed: 32832032; DOI: 10.1021/acsmedchemlett.0c00279

実験手法

X-RAY DIFFRACTION (2.38 Å)