6R58

Crystal structure of PPEP-1(E143A/Y178F/E184A) in complex with substrate peptide Ac-EVNAPVP-CONH2

Summary for 6R58

• Entry DOI: 10.2210/pdb6r58/pdb
• Descriptor: Pro-Pro endopeptidase, ACE-GLU-VAL-ASN-ALA-PRO-VAL-LPD, ZINC ION, ... (6 entities in total)
• Functional Keywords: pro-pro endopeptidase 1, zinc metallopeptidase, clostridium difficile, virulence factor, hydrolase
• Biological source: Peptoclostridium difficile; More
• Total number of polymer chains: 8
• Total formula weight: 90755.76

Authors

Pichlo, C.,Baumann, U. (deposition date: 2019-03-24, release date: 2019-06-12, Last modification date: 2024-01-24)

• Primary citation: Pichlo, C.,Juetten, L.,Wojtalla, F.,Schacherl, M.,Diaz, D.,Baumann, U.; Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.; J.Biol.Chem., 294:11525-11535, 2019; PubMed: 31182482; DOI: 10.1074/jbc.RA119.009029

Experimental method

X-RAY DIFFRACTION (1.9 Å)