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6R57

Crystal structure of PPEP-1(E143A/Y178F/E184A) in complex with substrate peptide Ac-EVNPPVP-CONH2

Summary for 6R57
Entry DOI10.2210/pdb6r57/pdb
DescriptorPro-Pro endopeptidase, ACE-GLU-VAL-ASN-PRO-PRO-VAL-LPD, ZINC ION, ... (4 entities in total)
Functional Keywordspro-pro endopeptidase 1, zinc metallopeptidase, clostridium difficile, virulence factor, hydrolase
Biological sourcePeptoclostridium difficile
More
Total number of polymer chains4
Total formula weight45320.42
Authors
Pichlo, C.,Baumann, U. (deposition date: 2019-03-24, release date: 2019-06-12, Last modification date: 2024-01-24)
Primary citationPichlo, C.,Juetten, L.,Wojtalla, F.,Schacherl, M.,Diaz, D.,Baumann, U.
Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
J.Biol.Chem., 294:11525-11535, 2019
Cited by
PubMed: 31182482
DOI: 10.1074/jbc.RA119.009029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.899 Å)
Structure validation

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