6R4V

Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate

6R4V の概要

• エントリーDOI: 10.2210/pdb6r4v/pdb
• 分子名称: Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, IBANDRONATE, ... (5 entities in total)
• 機能のキーワード: bisphosphonate, ibandronate, geranylgeranyl diphosphate, prenyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 215130.43

構造登録者

Lisnyansky, M.,Giladi, M.,Haitin, Y. (登録日: 2019-03-24, 公開日: 2019-09-18, 最終更新日: 2024-01-24)

• 主引用文献: Lisnyansky, M.,Yariv, E.,Segal, O.,Marom, M.,Loewenstein, A.,Ben-Tal, N.,Giladi, M.,Haitin, Y.; Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis.; Mol.Pharmacol., 96:580-588, 2019; PubMed: 31427399; DOI: 10.1124/mol.119.117499

実験手法

X-RAY DIFFRACTION (2.202 Å)