6QM8

Leishmania tarentolae proteasome 20S subunit apo structure

Summary for 6QM8

• Entry DOI: 10.2210/pdb6qm8/pdb
• EMDB information: 4591
• Descriptor: Proteasome alpha1 chain, Proteasome beta3 chain, Proteasome beta4 chain, ... (14 entities in total)
• Functional Keywords: proteasome 20s subunit, hydrolase
• Biological source: Leishmania tarentolae; More
• Total number of polymer chains: 28
• Total formula weight: 847844.50

Authors

Rowland, P.,Goswami, P. (deposition date: 2019-02-01, release date: 2019-04-17, Last modification date: 2019-12-18)

• Primary citation: Wyllie, S.,Brand, S.,Thomas, M.,De Rycker, M.,Chung, C.W.,Pena, I.,Bingham, R.P.,Bueren-Calabuig, J.A.,Cantizani, J.,Cebrian, D.,Craggs, P.D.,Ferguson, L.,Goswami, P.,Hobrath, J.,Howe, J.,Jeacock, L.,Ko, E.J.,Korczynska, J.,MacLean, L.,Manthri, S.,Martinez, M.S.,Mata-Cantero, L.,Moniz, S.,Nuhs, A.,Osuna-Cabello, M.,Pinto, E.,Riley, J.,Robinson, S.,Rowland, P.,Simeons, F.R.C.,Shishikura, Y.,Spinks, D.,Stojanovski, L.,Thomas, J.,Thompson, S.,Viayna Gaza, E.,Wall, R.J.,Zuccotto, F.,Horn, D.,Ferguson, M.A.J.,Fairlamb, A.H.,Fiandor, J.M.,Martin, J.,Gray, D.W.,Miles, T.J.,Gilbert, I.H.,Read, K.D.,Marco, M.,Wyatt, P.G.; Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.; Proc.Natl.Acad.Sci.USA, 116:9318-9323, 2019; PubMed: 30962368; DOI: 10.1073/pnas.1820175116

Experimental method

ELECTRON MICROSCOPY (3.3 Å)