6QM8

Leishmania tarentolae proteasome 20S subunit apo structure

Summary for 6QM8

EMDB information4591
DescriptorProteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ... (14 entities in total)
Functional Keywordsproteasome 20s subunit, hydrolase
Biological sourceLeishmania tarentolae
Total number of polymer chains28
Total molecular weight847844.5
Authors
Rowland, P.,Goswami, P. (deposition date: 2019-02-01, release date: 2019-04-17, Last modification date: 2019-05-22)
Primary citation
Wyllie, S.,Brand, S.,Thomas, M.,De Rycker, M.,Chung, C.W.,Pena, I.,Bingham, R.P.,Bueren-Calabuig, J.A.,Cantizani, J.,Cebrian, D.,Craggs, P.D.,Ferguson, L.,Goswami, P.,Hobrath, J.,Howe, J.,Jeacock, L.,Ko, E.J.,Korczynska, J.,MacLean, L.,Manthri, S.,Martinez, M.S.,Mata-Cantero, L.,Moniz, S.,Nuhs, A.,Osuna-Cabello, M.,Pinto, E.,Riley, J.,Robinson, S.,Rowland, P.,Simeons, F.R.C.,Shishikura, Y.,Spinks, D.,Stojanovski, L.,Thomas, J.,Thompson, S.,Viayna Gaza, E.,Wall, R.J.,Zuccotto, F.,Horn, D.,Ferguson, M.A.J.,Fairlamb, A.H.,Fiandor, J.M.,Martin, J.,Gray, D.W.,Miles, T.J.,Gilbert, I.H.,Read, K.D.,Marco, M.,Wyatt, P.G.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116:9318-9323, 2019
PubMed: 30962368 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1820175116
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers4 0.9% 10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6qm8
no rotation
Molmil generated image of 6qm8
rotated about x axis by 90°
Molmil generated image of 6qm8
rotated about y axis by 90°