Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA

Summary for 6QHD

DescriptorSignal transducer and activator of transcription 3, DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), ... (4 entities in total)
Functional Keywordslysine acetylation, dna binding, post translational modification, non canonical amino acid, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight147542.48
Arbely, E.,Belo, Y.,Shahar, A.,Zarivach, R. (deposition date: 2019-01-16, release date: 2019-06-19, Last modification date: 2019-06-26)
Primary citation
Belo, Y.,Mielko, Z.,Nudelman, H.,Afek, A.,Ben-David, O.,Shahar, A.,Zarivach, R.,Gordan, R.,Arbely, E.
Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
Biochim Biophys Acta Gen Subj, 1863:1343-1350, 2019
PubMed: 31170499 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbagen.2019.05.019
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.34314 1.5% 14.5% 13.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution