6QAT

Crystal structure of ULK2 in complexed with hesperadin

Summary for 6QAT

Entry DOI	10.2210/pdb6qat/pdb
Descriptor	Serine/threonine-protein kinase ULK2, N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide (3 entities in total)
Functional Keywords	ulk2, autophagy, kinase, inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	129137.50
Authors	Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (deposition date: 2018-12-19, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citation	Chaikuad, A.,Koschade, S.E.,Stolz, A.,Zivkovic, K.,Pohl, C.,Shaid, S.,Ren, H.,Lambert, L.J.,Cosford, N.D.P.,Brandts, C.H.,Knapp, S. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem.J., 476:875-887, 2019 Cited by PubMed: 30782972 DOI: 10.1042/BCJ20190038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation