6Q94

Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man

Summary for 6Q94

• Entry DOI: 10.2210/pdb6q94/pdb
• Descriptor: GDP-mannose 4,6 dehydratase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... (5 entities in total)
• Functional Keywords: gdp-mannose 4, 6 dehydratase, fucosylation, structural genomics, structural genomics consortium, sgc, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 331714.02

Authors

Pfeiffer, M.,Krojer, T.,Johansson, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Nidetzky, B.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-17, release date: 2019-04-24)

• Primary citation: Pfeiffer, M.,Johansson, C.,Krojer, T.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B.; A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.; Acs Catalysis, 9:2962-2968, 2019; PubMed: 30984471; DOI: 10.1021/acscatal.9b00064

Experimental method

X-RAY DIFFRACTION (2.8 Å)