6Q8P
Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine
Summary for 6Q8P
Entry DOI | 10.2210/pdb6q8p/pdb |
Descriptor | Dual specificity protein kinase CLK1, ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, inhibitor, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 119549.33 |
Authors | Joerger, A.C.,Chatterjee, D.,Schroeder, M.,Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Khiari, J.,Josselin, B.,Baratte, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-15, release date: 2019-02-20, Last modification date: 2024-01-24) |
Primary citation | Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Knapp, S.,Chatterjee, D.,Schroder, M.,Joerger, A.C.,Khiari, J.,Josselin, B.,Baratte, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P. New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166:304-317, 2019 Cited by PubMed: 30731399DOI: 10.1016/j.ejmech.2019.01.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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